Definition:Specialized cold chain for vaccines maintaining strict +2°C to +8°C (some vaccines require -20°C or ultra-low -70°C).
Critical Considerations::
- Cannot freeze (ice crystal damage destroys vaccine efficacy)
- Continuous temperature monitoring mandatory
- Chain of custody documentation
- Proper storage (never on door shelves)
- Last-in, first-out with expiry tracking
Regulatory:: WHO Expanded Programme on Immunization (EPI) guidelines, SAHPRA requirements.
Related Terms:: Pharmaceutical Range, GDP, Biological Products, Temperature-Sensitive